diff --git a/.travis.yml b/.travis.yml
index ed690253..8abe97fe 100644
--- a/.travis.yml
+++ b/.travis.yml
@@ -13,8 +13,6 @@ matrix:
       env: TOXENV=py,codecov
     - python: 2.7
       env: TOXENV=py,codecov
-    - python: 2.6
-      env: TOXENV=py,codecov
     - python: pypy
       env: TOXENV=py,codecov
     - python: nightly
diff --git a/CONTRIBUTING.rst b/CONTRIBUTING.rst
index f6ff7015..5ab6534a 100644
--- a/CONTRIBUTING.rst
+++ b/CONTRIBUTING.rst
@@ -109,7 +109,7 @@ depends on which part of Flask you're working on. Travis-CI will run the full
 suite when you submit your pull request.
 
 The full test suite takes a long time to run because it tests multiple
-combinations of Python and dependencies. You need to have Python 2.6, 2.7, 3.3,
+combinations of Python and dependencies. You need to have Python 2.7, 3.3,
 3.4, 3.5 3.6, and PyPy 2.7 installed to run all of the environments. Then run::
 
     tox
diff --git a/docs/deploying/fastcgi.rst b/docs/deploying/fastcgi.rst
index 5ca2a084..27a3a44e 100644
--- a/docs/deploying/fastcgi.rst
+++ b/docs/deploying/fastcgi.rst
@@ -111,7 +111,7 @@ Set yourapplication.fcgi::
     #!/usr/bin/python
     #: optional path to your local python site-packages folder
     import sys
-    sys.path.insert(0, '<your_local_path>/lib/python2.6/site-packages')
+    sys.path.insert(0, '<your_local_path>/lib/python2.7/site-packages')
 
     from flup.server.fcgi import WSGIServer
     from yourapplication import app
diff --git a/docs/installation.rst b/docs/installation.rst
index 0ae05f06..d700753f 100644
--- a/docs/installation.rst
+++ b/docs/installation.rst
@@ -7,7 +7,7 @@ Python Version
 --------------
 
 We recommend using the latest version of Python 3. Flask supports Python 3.3
-and newer, Python 2.6 and newer, and PyPy.
+and newer, Python 2.7 and PyPy.
 
 Dependencies
 ------------
diff --git a/flask/cli.py b/flask/cli.py
index bea4a29f..ca0ec927 100644
--- a/flask/cli.py
+++ b/flask/cli.py
@@ -724,9 +724,6 @@ def main(as_module=False):
     if as_module:
         this_module = 'flask'
 
-        if sys.version_info < (2, 7):
-            this_module += '.cli'
-
         name = 'python -m ' + this_module
 
         # Python rewrites "python -m flask" to the path to the file in argv.
diff --git a/scripts/flaskext_tester.py b/scripts/flaskext_tester.py
index 93ab0ad7..8a089562 100644
--- a/scripts/flaskext_tester.py
+++ b/scripts/flaskext_tester.py
@@ -284,7 +284,7 @@ def main():
                         help='run against all extensions, not just approved')
     parser.add_argument('--browse', dest='browse', action='store_true',
                         help='show browser with the result summary')
-    parser.add_argument('--env', dest='env', default='py25,py26,py27',
+    parser.add_argument('--env', dest='env', default='py27',
                         help='the tox environments to run against')
     parser.add_argument('--extension=', dest='extension', default=None,
                         help='tests a single extension')
diff --git a/setup.py b/setup.py
index bb2aab41..328f107f 100644
--- a/setup.py
+++ b/setup.py
@@ -95,7 +95,6 @@ setup(
         'Operating System :: OS Independent',
         'Programming Language :: Python',
         'Programming Language :: Python :: 2',
-        'Programming Language :: Python :: 2.6',
         'Programming Language :: Python :: 2.7',
         'Programming Language :: Python :: 3',
         'Programming Language :: Python :: 3.3',
diff --git a/tests/test_regression.py b/tests/test_regression.py
index d2c088f7..d467ab6c 100644
--- a/tests/test_regression.py
+++ b/tests/test_regression.py
@@ -62,9 +62,8 @@ def test_memory_consumption():
     # Trigger caches
     fire()
 
-    # This test only works on CPython 2.7.
-    if sys.version_info >= (2, 7) and \
-            not hasattr(sys, 'pypy_translation_info'):
+    # This test only works on CPython.
+    if not hasattr(sys, 'pypy_translation_info'):
         with assert_no_leak():
             for x in range(10):
                 fire()
diff --git a/tox.ini b/tox.ini
index 45d81b65..4804a756 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,9 +1,9 @@
 [tox]
 envlist =
-    py{36,35,34,33,27,26,py}
+    py{36,35,34,33,27,py}
     py{36,27,py}-simplejson
-    py{36,33,27,26,py}-devel
-    py{36,33,27,26,py}-lowest
+    py{36,33,27,py}-devel
+    py{36,33,27,py}-lowest
     docs-html
     coverage-report
 
@@ -59,8 +59,6 @@ passenv = CI TRAVIS TRAVIS_*
 deps = codecov
 skip_install = true
 commands =
-    # install argparse for 2.6
-    python -c 'import sys, pip; sys.version_info < (2, 7) and pip.main(["install", "argparse", "-q"])'
     coverage combine
     coverage report
     codecov